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doi: 10.1186/s40001-022-00691-2 105 HuangZ.BaiY.ChenY.ChenY.JiangY.ZhouJ

Although some authors have tried to assess the mechanistic link between HLA-II allele expression and the development of ME/CFS, the lack of robust data makes it difficult to support this association (88, 490)

Further, the downstream metabolic sequelae from enhanced acylglycine excretion and 1-carbon cycle activity in other organs and tissues should be explored in future efforts